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|Title: ||Impact of tuberculosis (TB) on HIV-1 activity in dually infected patients|
|Authors: ||Toossi, Z.|
Hirsch, C. S.
Edmonds, K. L.
Hom, D. L.
Ellner, J. J.
Whalen, C. W.
|Keywords: ||Mycobacterium tuberclosis|
|Issue Date: ||2001 |
|Citation: ||Toossi, Z., Mayanja-Kizza, H, Hirsch, C.S., Edmonds, K.L., Spahlinger, T., Hom, D.L., Aung, H., Mugyenyi, P., Ellner, J.J., Whalen, C.W. (2001). Impact of tuberculosis (TB) on HIV-1 activity in dually infected patients. Clinical and Experimental Immunology, 123|
|Abstract: ||Active TB in HIV-1-infected subjects is associated with increased HIV-1-related immunodeficiency and mortality. We assessed plasma viral load in HIV-1-infected patients with pulmonary TB (HIV/TB) and non-TB symptomatic HIV-1-infected patients (HIV). HIV-1 load was higher in HIV/TB compared with HIV at higher CD4 counts (. 500/ml) (P, 0´01), but not at lower CD4 counts (, 500/ml). We also evaluated the status of HIV-1 gene expression in peripheral blood mononuclear cells (PBMC) and serum from HIV/TB and CD4-matched healthy HIV-infected patients (HIV/C) by reverse transcriptase polymerase chain reaction over a range of CD4 (. 900/ml to ,200/ml). HIV-1 RNA in serum and PBMC correlated to one another, and both were markedly higher in HIV/TB compared with HIV/C with higher CD4 counts. Also, during a longitudinal study of anti-tuberculous chemoprophylaxis in HIV-1- infected patients, 10 subjects who developed TB had serologies before, at the time, and after the diagnosis of TB. These HIV/TB patients had an increase in viral load (average 2´5-fold) at the time of diagnosis of TB (P , 0´05). Overall, these data indicate that the transcriptional activity of HIV-1 is enhanced in HIV-1-infected patients with active TB, especially during early HIV-1 disease. As TB often is an early HIV-1 opportunistic infection, it may particularly favour early viral replication and dissemination, and therefore contribute to progression of HIV-1 disease.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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