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|Title: ||TLR9 Polymorphisms Are Associated with Altered IFN-γ Levels in Children with Cerebral Malaria|
|Authors: ||Nadia-Agudu, A. Sam|
Greene, Jennifer A.
Opoka, Robert O.
Kazura, James W.
Boivin, Michael J.
Zimmerman, Peter A.
Riedesel, Melissa A.
Bergemann, Tracy L.
Schimmenti, Lisa A.
John, Chandy C.
Plasmodium falciparum parasitemia
Cerebral malaria (CM)
Pathogenesis of CM
Toll-like receptors (TLRs
|Issue Date: ||2010 |
|Publisher: ||American Society of Tropical Medicine and Hygiene|
|Citation: ||Nadia-Agudu, A.S., Greene, J.A., Opoka, R.O., Kazura, J.W., Boivin, M.J., Zimmerman, P.A., Riedesel, M.A., Bergemann, T.L., Schimmenti, L.A., John, C.C. (2010). TLR9 Polymorphisms are associated with altered IFN-γ levels in children with cerebral malaria. American Journal of Tropical Medicine and Hygiene, 82(4)|
|Abstract: ||Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at −1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at −1237 or the G allele at 1174 had higher levels of IFN-γ than those without these alleles ( P = 0.03 and 0.008, respectively). The TLR9 SNPs were
not associated with altered IFN-γ levels in children with UM or altered TNF-α levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.|
|Appears in Collections:||Research Articles (Health-Sciences)|
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