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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1648
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| Title: | TLR9 Polymorphisms Are Associated with Altered IFN-γ Levels in Children with Cerebral Malaria |
| Authors: | Nadia-Agudu, A. Sam
Greene, Jennifer A.
Opoka, Robert O.
Kazura, James W.
Boivin, Michael J.
Zimmerman, Peter A.
Riedesel, Melissa A.
Bergemann, Tracy L.
Schimmenti, Lisa A.
John, Chandy C. |
| Keywords: | Children
Plasmodium falciparum parasitemia
Cerebral malaria (CM)
Serum levels
Pathogenesis of CM
Pathological evidence
Toll-like receptors (TLRs
Microbial ligands
Malaria
Children
Pro-inflammatory cytokines |
| Issue Date: | 2010 |
| Publisher: | American Society of Tropical Medicine and Hygiene |
| Citation: | Nadia-Agudu, A.S., Greene, J.A., Opoka, R.O., Kazura, J.W., Boivin, M.J., Zimmerman, P.A., Riedesel, M.A., Bergemann, T.L., Schimmenti, L.A., John, C.C. (2010). TLR9 Polymorphisms are associated with altered IFN-γ levels in children with cerebral malaria. American Journal of Tropical Medicine and Hygiene, 82(4) |
| Abstract: | Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at −1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at −1237 or the G allele at 1174 had higher levels of IFN-γ than those without these alleles ( P = 0.03 and 0.008, respectively). The TLR9 SNPs were
not associated with altered IFN-γ levels in children with UM or altered TNF-α levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection. |
| URI: | http://doi:10.4269/ajtmh.2010.09-0467
http://hdl.handle.net/123456789/1648 |
| ISSN: | 0002-9637 |
| Appears in Collections: | Research Articles (Health-Sciences)
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