|
|
Makerere University Research Repository >
College of Health Sciences >
School of Health Sciences >
Research Articles (Health-Sciences) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1641
|
| Title: | Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda |
| Authors: | Luzze, H.
Elliott, A. M.
Odida, M.
Joloba, M. L.
Oweka-Onyee, J.
Nakiyingi, J.
Quigley, M.
Okwera, A. |
| Keywords: | Tuberculosis
HIV/AIDS
Lung diseases
Uganda
Pleural tuberculosis
TB |
| Issue Date: | Apr-2001 |
| Publisher: | International Union Against Tuberculosis and Lung Disease |
| Citation: | Luzze, H., Elliott, A.M., Odida, M., Joloba, M.L., Oweka-Onyee, J., Nakiyingi, J., Quigley, M., Okwera, A. (2001). Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda. International Journal of Tuberculosis and Lung Disease, 5(8) |
| Abstract: | SETTING: National Tuberculosis Treatment Centre, Mulago Hospital, Kampala, Uganda.
OBJECTIVES: To compare clinical and radiographic presentation, and diagnostic methods, in adults with tuberculous pleurisy who are negative and positive for the human immunodeficiency virus (HIV).
DESIGN: Adults with suspected pleural tuberculosis were screened by clinical examination, thoracocentesis and closed pleural biopsy. Biopsy material was cultured on Middlebrook 7H-10 solid medium and in BACTEC 12B radiometric vials. Pleural fluid was cultured using Löwenstein-Jensen slants, BACTEC and Kirchner liquid medium.
RESULTS: Of 156 individuals enrolled, 142 had tuberculosis, of whom 80% were HIV-positive. Among those with tuberculosis, HIV-positive patients had a more severe and longer illness. The size of effusions was similar in HIV-positive and HIV-negative patients. A higher proportion of HIV-positive patients had parenchymal infiltrates but this difference was not statistically significant. Pleural fluid lymphocytosis was present in all HIVnegative and 97% of the HIV-positive patients. HIVpositive patients had lower pleural fluid lymphocyte counts. Pleural fluid cultures were more often positive in HIV positive patients. BACTEC and Kirchner liquid media gave higher yields than solid media.
CONCLUSION: HIV-positive patients with tuberculous pleurisy had a more severe illness than HIV-negative patients. Mycobacterial cultures from HIV-positive patients were more often positive, suggesting more mycobacterial extension from the lungs into the pleural space. Liquid culture media were superior to solid media with regard to diagnostic yield and time until diagnosis. |
| URI: | http://hdl.handle.net/123456789/1641 |
| ISSN: | 1027-3719 |
| Appears in Collections: | Research Articles (Health-Sciences)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| luzze-chs-res.pdf | | 121Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
