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|Title: ||Tanrıverdi, S., et al. (2008). Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis|
|Authors: ||Tanriverdi, Sultan|
Chalmers, Rachel M.
Hunter, Paul R.
Akiyoshi, Donna E.
Tumwine, James K.
|Keywords: ||Cryptosporidium parvum|
|Issue Date: ||Dec-2008 |
|Publisher: ||American Society for Microbiology|
|Citation: ||Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis. Applied Environmental Microbiology, 74(23):7227-7234|
|Series/Report no.: ||Applied Environmental Microbiology|
|Abstract: ||Cryptosporidium parvum and Cryptosporidium hominis are two related species of apicomplexan protozoa
responsible for the majority of human cases of cryptosporidiosis. In spite of their considerable public health
impact, little is known about the population structures of these species. In this study, a battery of C. parvum
and C. hominis isolates from seven countries was genotyped using a nine-locus DNA subtyping scheme. To
assess the existence of geographical partitions, the multilocus genotype data were mined using a cluster
analysis based on the nearest-neighbor principle. Within each country, the population genetic structures were
explored by combining diversity statistical tests, linkage disequilibrium, and eBURST analysis. For both
parasite species, a quasi-complete phylogenetic segregation was observed among the countries. Cluster analysis
accurately identified recently introduced isolates. Rather than conforming to a strict paradigm of either
a clonal or a panmictic population structure, data are consistent with a flexible reproductive strategy characterized
by the cooccurrence of both propagation patterns. The relative contribution of each pattern appears
to vary between the regions, perhaps dependent on the prevailing ecological determinants of transmission|
|Appears in Collections:||Research Articles (Sch. of Med.)|
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