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|Title: ||Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic|
|Authors: ||Nsobya, Samuel L.|
Rosenthal, Philip J.
|Issue Date: ||8-Mar-2006 |
|Publisher: ||American Society for Microbiology|
|Citation: ||Nsobya, S.L., Dokomajilar, C., Greenhouse, B., Rosenthal, P.J., Dorsey, G. (2006). Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrobial Agents and Chemotherapy -Journal-, 50(5)|
|Abstract: ||Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug|
|Appears in Collections:||Research Articles (Health-Sciences)|
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