|
|
Makerere University Research Repository >
College of Health Sciences >
School of Health Sciences >
Research Articles (Health-Sciences) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1471
|
| Title: | Type-specific incidence, clearance and predictors of cervical human papillomavirus infections (HPV) among young women: a prospective study in Uganda. |
| Authors: | Banura, Cecil
Sandin, Sven
van Doorn, Leen-Jan
Quint, Wim
Kleter, Bernhard
Wabwire-Mangen, Fred
Mbidde, Edward K
Weiderpass, Elisabete |
| Keywords: | Human papillomavirus (HPV)
HIV/AIDS
Sexually active young
Uganda |
| Issue Date: | 2010 |
| Publisher: | BioMed Central |
| Citation: | Banura, C., Sandin, S., van Doorn, L.J., Quint, W., Kleter, B., Wabwire-Mangen, F., Mbidde, E.K., Weiderpass , E. (2010). Type-specific incidence, clearance and predictors of cervical human papillomavirus infections (HPV) among young women: a prospective study in Uganda. Infectious Agents and Cancer, 5(7) |
| Abstract: | Background: While infections with human papillomavirus (HPV) are highly prevalent among sexually active young
women in Uganda, information on incidence, clearance and their associated risk factors is sparse. To estimate the
incidence, prevalence and determinants of HPV infections, we conducted a prospective follow-up study among 1,275
women aged 12-24 years at the time of recruitment. Women answered a questionnaire and underwent a pelvic
examination at each visit to collect exfoliated cervical cells. The presence of 42 HPV types was evaluated in exfoliated
cervical cells by a polymerase chain based (PCR) assay (SPF10-DEIA LiPA).
Results: Three hundred and eighty (380) of 1,275 (29.8%) women were followed up for a median time of 18.5 months
(inter-quartile range 9.7-26.6). Sixty-nine (69) women had incident HPV infections during 226 person-years of follow-up
reflecting an incidence rate of 30.5 per 100 person-years. Incident HPV infections were marginally associated with HIV
positivity (RR = 2.8, 95% CI: 0.9 - 8.3). Clearance for HPV type-specific infections was frequent ranging between 42.3%
and 100.0% for high- and 50% and 100% for low-risk types. Only 31.2% of women cleared all their infections. Clearance
was associated with HIV negativity (Adjusted clearance = 0.2, 95% CI: 0.1 - 0.7) but not with age at study entry, lifetime
number of sexual partners and multiplicity of infections. The prevalence of low-grade squamous intraepithelial lesions
(LSILs) was 53/365 (14.5%). None of the women had a high-grade cervical lesion (HSIL) or cancer. Twenty-two (22) of
150 (14.7%) HPV negative women at baseline developed incident LSIL during follow-up. The risk for LSIL appeared to
be elevated among women with HPV 18-related types compared to women not infected with those types (RR = 3.5,
95% CI: 1.0 - 11.8).
Conclusions: Incident HPV infections and type-specific HPV clearance were frequent among our study population of
young women. These results underscore the need to vaccinate pre-adolescent girls before initiation of sexual activity. |
| URI: | http://www.infectagentscancer.com/content/5/1/7
http://hdl.handle.net/123456789/1471 |
| Appears in Collections: | Research Articles (Health-Sciences)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| Banura-chs-res.pdf | | 904Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
