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|Title: ||Antiretroviral therapy in developing countries: pharmacologic considerations|
|Authors: ||Lamorde, Mohammed|
|Keywords: ||Anti-HIV agents|
|Issue Date: ||2008 |
|Publisher: ||Lippincott Williams & Wilkins|
|Citation: ||Lamorde M,Byakika-Kibwika P,Merry C. Antiretroviral therapy in developing countries: pharmacologic considerations Vol 3|
|Abstract: ||Purpose of review
This article reviews recent studies in the field of clinical pharmacology of antiretroviral drugs and highlights the relevance of the findings to clinical practice in developing countries.
Differences in antiretroviral pharmacokinetics are associated with polymorphisms of
genes encoding drug metabolizing enzymes. Inadequate concentrations of
antiretrovirals in children are common. A study in African children found subtherapeutic
concentrations in 40% of patients receiving efavirenz at recommended doses.
Recent findings on the pharmacokinetics of antiretroviral agents relevant to clinical
practice in developing countries are reviewed. Widespread poverty impacts negatively on HIV/AIDS treatment and prevention efforts. Improved access to treatment, social and economic support and pharmacology research in target populations are needed.|
|Appears in Collections:||Research Articles (IDI)|
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