|
Makerere University Research Repository >
College of Health Sciences >
Infectious Diseases Institute >
Research Articles (IDI) >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1427
|
| Title: | A new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries |
| Authors: | Colebunders, Robert
Moses, Kamya R
Laurence, John
Shihab, Hasan M
Semitala, Fred
Lutwama, Fred
Bakeera-Kitaka, Sabrina
Lynen, Lut
Spacek, Lisa
Reynolds, Steven J
Quinn, Thomas C
Viner, Brant
Mayanja-Kizza, Harriet |
| Keywords: | antiretroviral therapy
developing countries
HIV patients
resource-limited settings
virological efficacy
Virological monitoring |
| Issue Date: | 2006 |
| Publisher: | Lancet Infect Dis |
| Abstract: | Monitoring the efficacy of antiretroviral treatment in developing countries is difficult because these countries
have few laboratory facilities to test viral load and drug resistance. Those that exist are faced with a shortage of
trained staff, unreliable electricity supply, and costly reagents. Not only that, but most HIV patients in resourcepoor
countries do not have access to such testing. We propose a new model for monitoring antiretroviral
treatment in resource-limited settings that uses patients’ clinical and treatment history, adherence to treatment,
and laboratory indices such as haemoglobin level and total lymphocyte count to identify virological treatment
failure, and offers patients future treatment options. We believe that this model can make an accurate diagnosis
of treatment failure in most patients. However, operational research is needed to assess whether this strategy
works in practice. |
| URI: | http://infection.thelancet.com
http://hdl.handle.net/123456789/1427 |
| Appears in Collections: | Research Articles (IDI)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| Robert Colebunders- idi-res1.pdf | | 92Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
