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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1416
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| Title: | Human papillomavirus infection and squamous cell carcinoma of the conjunctiva |
| Authors: | Ateenyi-Agaba, C.
Franceschi, S.
Wabwire-Mangen, F.
Arslan, A.
Othieno, E.
Binta-Kahwa, J.
van Doorn, L.J
Kleter, B
Quint, W.
Weiderpass, E. |
| Keywords: | Human papillomaviruses
Squamous cell carcinoma
Conjunctiva
HPV |
| Issue Date: | 2010 |
| Publisher: | Nature Publishing Group |
| Citation: | Ateenyi-Agaba, C., Franceschi, S., Wabwire-Mangen, F., Arslan, A., Othieno, E., Binta-Kahwa, J., van Doorn, L.J., Kleter, B., Quint, W., Weiderpass, E. (2010). Human papillomavirus infection and squamous cell carcinoma of the conjunctiva. British Journal of Cancer, 102 |
| Abstract: | BACKGROUND: Squamous cell carcinoma of the conjunctiva (SCCC) is associated with HIV-related immunosuppression, but human
papillomavirus virus (HPV) is also suspected to have a role. We carried out a case–control study to assess the role of cutaneous and
mucosal HPV types in SCCC, conjunctival dysplasia, and their combination (SCCC/dysplasia) in Uganda.
METHODS: We compared HPV prevalence in frozen biopsies from 94 SCCC cases (79 of whom were found to be HIV-positive), 39
dysplasia cases (34 HIV-positive), and 285 hospital controls (128 HIV-positive) having other eye conditions that required surgery.
Highly sensitive PCR assays that detect 75 HPV types were used. Odds ratios (ORs) and 95% confidence intervals (CIs) were
computed, adjusting for, or stratifying by age, sex, and HIV status.
RESULTS: Cutaneous HPV types were detected in 45% of SCCC cases, 41% of dysplasia cases and 11% of controls. Human
papillomavirus virus 5 and 8 were the most common types in SCCC, and most often occurred in combination with other types.
Associations were observed between SCCC/dysplasia and detection of both single (OR¼2.3; 1.2–4.4) and multiple (OR¼18.3;
6.2–54.4) cutaneous HPV types, and were chiefly based on findings in HIV-positive patients. Cutaneous HPV infections were rarely
observed among HIV-negative patients and the association with SCCC/dysplasia was not significant (OR¼2.4; 0.6–9.6) among them.
Squamous cell carcinoma of the conjunctiva/dysplasia risk and mucosal HPV types were not associated in either HIV-positive or
HIV-negative patients.
CONCLUSIONS: We detected cutaneous HPV types in nearly half of SCCC/dysplasia cases and often multiple types (HPV5 and 8 being
most common). The role of HIV (confounder or strong enhancer of cutaneous HPV carcinogenicity) is still uncertain. |
| URI: | http://hdl.handle.net/123456789/1416 |
| ISSN: | 0007-0920 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| Ateenyi-Agaba-chs-res.pdf | | 239Kb | Adobe PDF | View/Open |
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