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|Title: ||Quantitative sputum bacillary load during rifampin-containing short course chemotherapy in human immunodeficiency virus-infected and non-infected adults with pulmonary tuberculosis|
|Authors: ||Joloba, M. L.|
Johnson, J. L.
Assegghai, A. E.
Mugerwa, R. D.
Ellner, J. J.
Eisenach, K. D.
Colony forming units
|Issue Date: ||22-Jan-2000 |
|Publisher: ||International Union Against Tuberculosis and Lung Disease|
|Citation: ||Joloba, M., Namale, A., Johnson, J.L., Morrissey, A., Assegghai, A. E., Mugerwa, R.D., Eisenach, K.D., Ellner, J.J. (2000). Quantitative sputum bacillary load during rifampin containing short course chemotherapy in human immunodeficiency virus-infected and non-infected adults with pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease, 4(6)|
|Abstract: ||SETTING: National Tuberculosis (TB) Treatment Centre, Mulago Hospital and Joint Clinical Research Centre, Kampala, Uganda.
OBJECTIVE: To compare the quantitative sputum bacillary load between TB patients infected with the human immunodeficiency virus (HIV) and those non-infected,
during treatment with standard short course chemotherapy(SCC).
DESIGN: To compare clinical characteristics and quantitative sputum bacillary load as measured by quantitative acid-fast bacilli (AFB) smears, colony forming unit
(cfu) assay and time until positive culture in the BACTEC® radiometric liquid system between 14 HIVinfected and 22 non-HIV-infected adults with initial episodes
of smear-positive pulmonary TB at baseline and during treatment with standard four-drug SCC.
RESULTS: Other than cavitation (P = 0.042) and adenopathy (P = 0.03), which were more common among non-HIV-infected and HIV-infected patients, respectively, there were no significant differences in baseline
demographic, clinical, radiological and laboratory characteristics between the groups. Mean pretreatment sputum
bacillary burden (6.5 ± 0.51 log10 AFB/ml, 5.91 ± 0.91 log10 cfu/ml and 1.8 ± 1.7 days until positive BACTEC® culture for HIV-infected patients and 6.32 ± 0.85 log10 AFB/ml, 5.58 ± 0.68 log10 cfu/ml and 1.9 ± 1.2 days until positive BACTEC® culture for non-HIVinfected
patients) were comparable between HIV-infected and non-HIV-infected patients. Clinical and bacteriological
responses to standard SCC and treatment outcome did not differ between the groups.
CONCLUSION: Quantitative sputum bacillary load at baseline and during SCC did not differ significantly between HIV-infected and non-HIV-infected adults with
initial episodes of smear-positive TB.|
|Appears in Collections:||Research Articles (Bio-Medical)|
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