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Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/1291
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| Title: | Targeting persistent HIV infection: where and how, if possible? |
| Authors: | Wayengera, Misaki |
| Keywords: | HIV sanctuaries
Cellular reservoirs
Anatomic hide-outs
Towards-an-HIV-cure |
| Issue Date: | 2011 |
| Publisher: | Elsevier |
| Citation: | HIV & AIDS Review, 10(1): 1-8 |
| Abstract: | Sanctuaries of persistent human immunodeficiency virus (HIV) infection, which are diverse and stillincompletely
resolved, account for the incomplete clearance of HIV among infected persons with a
long-standing history of highly active antiretroviral therapy-HAART use. Specifically, sanctuaries of
both actively replicating, and latent-virus make-up a source of rebound-viremia in persons living with
HIV/AIDS (PLWHA) who, either stop or default-from HAART, even when there was prior demonstrable
effective viral suppression and attainment of undetectable viral loads (<50 copies HIVRNA/mlby ultrasensitive
single copy assays). To sustain viral suppression, persons infected with HIV must hence indefinitely
stay on HAART. Targeting sites of persistent HIV-infection therefore becomes a pivotal strategy towards
achieving HIV therapeutic cure by way of HAART. In order to devise means to counter persistent HIV
infection-we note that, one must understand where and how this occurs. A review of persistent HIV
niches is presented here within a holistic frame work that recognizes HIV to hide both at the cellular
(latent-infection) and anatomic (active-infection) levels. Accordingly, the potential models for anti-HIV
persistence should consist of (a) mechanisms to exorcise or flush out non-expressed or repressed host
genome integrated proviral DNA, and (b) drug delivery strategies to intensify HAART access to unreachable
anatomic hide-outs. Novel approaches to, either prevent the primary integration of HIV DNA into
host genomes or kill-off those cell types chronically infected with HIV, are sought. |
| Description: | Access to this item is restricted. Please contact the author for the full-text. |
| URI: | http://www.elsevier.com/locate/hivar
http://dx.doi.org/10.1016/j.hivar.2011.01.002
http://hdl.handle.net/123456789/1291 |
| ISSN: | 1730-1270 |
| Appears in Collections: | Research Articles (Health-Sciences)
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| wayengera-chs-res.pdf | | 319Kb | Adobe PDF | View/Open |
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