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|Title: ||Hepatitis B virus and sexual behavior in Rakai, Uganda.|
|Authors: ||Stabinski, Lara|
Reynolds, Steven J.
Gray, Ron H.
Thomas, David L.
Quinn, Thomas C.
Kirk, Gregory D.
|Keywords: ||Hepatitis B virus (HBV)|
Rakai District, Uganda
|Issue Date: ||2011 |
|Abstract: ||HIV and hepatitis B virus (HBV) co-infection
poses important public health considerations
in resource-limited settings. Demographic data and sera from adult participants of the Rakai Health Sciences Program Cohort in South Western Uganda were examined to determine HBV seroprevalence patterns in this area of high HIV endemicity prior to the introduction of anti-retroviral
therapy. Commercially available EIAs were
used to detect prevalent HBV infection (positive for HBV core antibody [anti-HBc] and/or positive HBV surface antigen [HBsAg]), and chronic infection (positive for HBsAg). Of 438 participants, 181
(41%) had prevalent HBV infection while 21 (5%) were infected chronically. Fourteen percent of participants were infected with HIV. Fifty three percent showed evidence of prevalent HBV infection compared to 40% among participants infected with HIV (P ¼ 0.067). Seven percent of participants infected with HIV were HBsAg positive compared to 4% among participants not infected with HIV (P ¼ 0.403). The prevalence
of prevalent HBV infection was 55% in adults
aged >50 years old, and 11% in persons under
20 years. In multivariable analysis, older age, HIV status, and serologic syphilis were significantly associated with prevalent HBV infection. Transfusion status and receipt of injectionswere not significantly associated with HBV infection. Contrary to expectations that HBV exposure in Uganda occurred chiefly during childhood, prevalent HBV infection was found to increase with age and was associated sexually transmitted diseases (HIV and syphilis.)Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority.|
|Description: ||Stabinski, L., Reynolds, S.J., Ocama, P., Laeyendecker, O., Serwadda, D., Gray, R.H., Wawer, M., Thomas, D. L., Quinn, T.C., Kirk, G.D. (2011). Hepatitis B virus and sexual behavior in Rakai, Uganda. Journal of Medical Virology, 83|
|Appears in Collections:||Research Articles (Health-Sciences)|
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