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|Title: ||Smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within reservoirs|
|Authors: ||Wayengera, Misaki|
|Keywords: ||HIV/AIDS treatment|
|Issue Date: ||Jul-2010 |
|Publisher: ||International Conference on AIDS|
|Citation: ||International Conference on AIDS 2010 July 18-23, Track A: abstract No. TUPE0034.|
|Abstract: ||Infection with human Immunodeficiency virus (HIV) remains a fatal occurrence despite advances in highly active antiretroviral therapy (HAART). In as much as the use of HAART is associated improvements in the quality and length of survival-time for those persons living with HIV/AIDS on HAART, HAART does not offer cure
HIV is capable of evading HAART, either by becoming latent as proviral HIV DNA integral within host genomes, or hiding as whole, free HIV virions in sanctuaries where HAART access is restricted .
Dealing with persistent HIV infections is a critical strategy towards achieving HIV cure 
While several TCR activation strategies— aimed at “flushing out” latent proviral HIV DNA from within host genomes, are being researched, there is no clear cut strategy to tackle whole, free virions within drug-inaccessible sanctuaries . Novel, highly innovative drug delivery strategies are therefore called for to ensure HAART access to whole, free HIV virion reservoirs.
This work aims to describe a novel approach for the construct of smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within Reservoirs.|
|Description: ||An e-poster presented at the XVIII AIDS conference in Vienna, July 18-23, 2010.|
|Appears in Collections:||Conference and Workshop Reports (Bio-Medical)|
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|wayengera-misaki-chs-eposter.pdf||AIDS-2010 E-Poster||158Kb||Adobe PDF||View/Open|
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