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Smart, nano-engineered drug (NRTI)-immune conjugates for targeting HIV within reservoirs
(BioMed Central, 2011-07-22)
Background: Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or ...
Comparison of transformation frequencies of commonly drug resistant and suceptible serotypes of streptococcus pneumoniae.
(2009-09)
Streptococcus pneumonia (pneumonococcus) is a leading human respiratory pathogen that causes a variety of serious mucosal and invasive diseases. There are atleast 90 serotypes of pneumonococcus but it has long been observed ...
Quantitative assessment of the sensitivity of various commercial reverse transcriptases based on armored HIV RNA
(Public Library of Science, 2010)
Background: The in-vitro reverse transcription of RNA to its complementary DNA, catalyzed by the enzyme reverse transcriptase, is
the most fundamental step in the quantitative RNA detection in genomic studies. As such, ...
Detection of mycobacterium tuberculosis complex DNA in CD34 positive versus CD34-Negative peripheral blood mononuclear cells and the determinants of IGRA positivity in latent Tuberculosis
(Makerere University, 2023)
Background
Tuberculin skin test (TST) and interferon gamma release assay (IGRA), currently used to diagnose latent
tuberculosis infection (LTBI) have low positive predictive values for progression to active tuberculosis ...