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Now showing items 21-30 of 92
Elevated natural killer cell activity despite altered functional and phenotypic profile in Ugandans with HIV-1 Clade A or Clade D infection.
(Lippincott Williams & Wilkins, 2009)
Background and Objective: Natural killer (NK) cells most likely contribute toward limiting HIV-1 replication, and investigation into their function throughout the course of infection is therefore important. We here aimed ...
The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda
(Makerere University Medical School, 2008-03)
Background: Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections. Objective: To ...
Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population
(Public Library of Science, 2009-11-11)
Background: Sepsis likely contributes to the high burden of infectious disease morbidity and mortality in low income countries. Data regarding sepsis management in sub-Saharan Africa are limited. We conducted a prospective ...
Voluntary HIV counselling and testing among men in rural western Uganda: Implications for HIV prevention
(BioMed Central, 2008-07-30)
Background: Voluntary HIV counselling and testing (VCT) is one of the key strategies in the prevention and control of HIV/AIDS in Uganda. However, the utilization of VCT services particularly among men is low in Kasese ...
Tuberculosis in household contacts of infectious cases in Kampala, Uganda
(2003)
Tuberculosis remains a serious threat to public health, especially in sub-Saharan Africa. To determine the host and environmental factors responsible for tuberculosis in African households, the authors performed a prospective ...
Digital clubbing in tuberculosis – relationship to HIV infection, extent of disease and hypoalbuminemia
(BioMed Central, 2006-03-10)
Background: Digital clubbing is a sign of chest disease known since the time of Hippocrates. Its association with tuberculosis (TB) has not been well studied, particularly in Africa where TB is common. The prevalence of ...
Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda
(Lippincott, Williams & Wilkins, 2007)
Objective: To evaluate adherence, treatment interruptions, and outcomes in patients purchasing antiretroviral fixed-dose combination (FDC) therapy. Design: Ninety-seven participants were recruited into a prospective 24-week ...
Risk factors and seroprevalence of Hepatitis C among patients hospitalised at Mulago Hospital, Uganda
(Hindawi Publishing Corporation, 2011-06-01)
The emergence of hepatitis C virus (HCV) and its associated sequelae in Africa is a cause for significant concern. Human immunodeficiency virus (HIV) positive patients are at an increased risk of contracting HCV infection ...
A novle polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single dose efavirenz population pharmacokinetics in Ugandans
(Wiley-Blackwell, 2009)
AIMS Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim was to develop an integrated population pharmacokinetic/pharmacogenetic model and investigate the impact of genetic variations, ...
Strategies to optimize HIV treatment outcomes in resource-limited settings
(Permanyer Publications, 2009)
Although the availability of antiretroviral therapy has increased rapidly to reach over three million people in low- and middle-income countries, coverage remains low as only 31% of people in need were receiving antiretroviral ...