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Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection
(International Medical Press, 2012)
BACKGROUND:
Here, we aimed to determine the clinical spectrum, predictors and outcomes of paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a resource-limited setting.
METHODS:
In a ...
The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country
(Public Library of Science, 2011-11)
Objective: To determine the need for routine speciation of positive Lowenstein-Jensen mycobacterial cultures in HIVinfected
patients suspected of having pulmonary tuberculosis at Mulago Hospital in Kampala, Uganda.
Methods: ...
Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia
(SciVerse ScienceDirect, 2012-02-15)
Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)–infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed ...
Bronchoalveolar lavage enzyme-linked immunospot for diagnosis of smear-negative tuberculosis in HIV infected patients
(Public Library of Science, 2012-06-26)
Background: Peripheral blood interferon-gamma release assays (IGRAs) have sub-optimal sensitivity and specificity for diagnosis of active pulmonary tuberculosis (TB). However, assessment of local immune responses has been ...
The aetiology of pulmonary infections among AAFB sputum smear negative HIV adults presenting to Mulago hospital
(2000)
Background: Pulmonary infections are an important cause of complications in up to 60% of HIV infected patients during the course of their disease. Tuberculosis (TB) is a common cause of such infections. Sub-Saharan Africa ...
Coping with TB immune reconstitution inflammatory syndrome
(Expert Reviews, 2009)
The TB immune reconstitution inflammatory syndrome (IRIS) is a relatively frequent complication in HIV–TB-coinfected patients after they start highly active antiretroviral therapy (HAART). There are two forms of TB IRIS: ...
In reply to `Empirical tuberculosis treatment or improved diagnostics?'
(International Union Against Tuberculosis and Lung Disease, 2012-02-16)
We read the article by Lawn and colleagues with great interest. Atypical presentation and limited diagnostic capability in resource-limited settings lead to delays in treatment that could contribute to high rates of ...
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
(Elsevier, 2008-08)
The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ...
Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy
(Lippincott Wilkins & Williams, 2011)
Background: Tuberculosis-HIV (TB-HIV) coinfection remains an
important cause of mortality in antiretroviral therapy (ART)
programs. In a cohort of TB-HIV–coinfected patients starting
ART, we examined the incidence and ...
Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV prevalence setting: a prospective cohort study
(Public Library of Science, 2011-01)
Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. ...