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How reliable are hematological parameters in predicting uncomplicated plasmodium falciparum malaria in an Endemic Region?
(Hindawi Publishing Corporation, 2013)
Background. Malaria remains endemic in Sub-Saharan Africa. Hematological changes that occur have been suggested as potential predictors of malaria. This study was aimed at evaluating the diagnostic relevance of hematological ...
Complexity of plasmodium falciparum clinical samples from Uganda during short-term culture.
(University of Chicago Press, 2008-08-22)
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture ...
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
(Makerere University, 2010)
Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ...
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
(Oxford University Press, 2009-11-04)
Background. Amodiaquine (AQ) is paired with artesunate (AS) or sulfadoxine-pyrimethamine (SP) in recommended antimalarial regimens. It is unclear how readily AQ resistance will be selected with combination chemotherapy. ...
Selection of plasmodium falciparum pfmdr1 Alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
(American Society for Microbiology, 2006-03-08)
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N,184F, and 1246D ...
Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
(University of Chicago Press, 2006-03-13)
Malaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies ...
Campylobacter spp among Children with acute diarrhea attending Mulago hospital in Kampala - Uganda
(2002-05)
Introduction HIV positive (HIV+) women are more susceptible to malaria infection during pregnancy than their HIV negative (HIV-) counterparts but the actual prevalence of infection in Ugandan pregnant women is not known. ...
Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria
(Lippincott Wilkins & Williams, 2008)
Background: Inpatient treatment for malaria without microscopic confirmation of the diagnosis occurs commonly in sub-Saharan Africa. Differences in mortality in children who are tested by microscopy for Plasmodium falciparum ...
Iron status in patients with plasmodium falciparum malaria and anaemia in Mulago hospital
(2002)
Malaria is an important cause of morbidity and mortality in Uganda. It is associated with a wide range of complications including severe anaemia especially in children. Anaemia impairs motor and cognitive development in ...
Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria (Review)
(Cochrane Collaboration, 2010)
Background
Multiple-drug-resistant malaria is widespread, and in South-East Asia resistance is high against nearly all single therapy antimalarial drugs. Here, and in other areas with low malaria transmission, the combination ...