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Pharmacokinetic interactions between chloroquine, sulfadoxine and pyrimethamine and their bioequivalence in a generic fixed-dose combination in healthy volunteers in Uganda
(African Health Sciences, 2006)
Background: A pre-packaged fixed-dose formulation of chloroquine (CQ) and sulfadoxine/pyrimethamine (S/P) combination (Homapak) is widely used for the treatment of falciparum malaria in Ugandan children. It is however a ...
Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: Experience with fixed-dose formulation
(Acta Tropica, 2006)
Amodiaquine (AQ) is an affordable compound, chemically related to chloroquine (CQ) but often effective against CQ resistant Plasmodium falciparum. In Uganda, a pre-packed fixed-dose combination of CQ plus sulfadoxine/pyrimethamine ...
Domestic violence during pregnancy in Uganda: the social context, biomedical consequences and relationship with induced abortion
(Axis Printers, 2006-05)
Background: The 2000/2001 Uganda Demographic and Health Surveillance report indicated that domestic violence, unwanted pregnancies and induced abortion were common reproductive health problems in Uganda. Women’s and men’s ...
Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts
(BioMed Central, 2006-10-16)
Background: The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. ...
c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population
(East African Medical Journal, 2006-08)
Objective: To evaluate c-erbB-2 oncoprotein over expression in breast cancer patients of Kyadondo county and also relate this oncoprotein to histological type and grade of the tumour. Design: Cross-sectional study. Setting: ...
Examining the nexus between nature, wealth and power in the Lake George fishery: a case of major actors in the fish product chain
(2006)
This briefing paper arises out of one of ACODE’s current research undertakings meant to influence policy processes in biodiversity conservation through generation of policy relevant information. The main aim of this paper ...
A new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries
(Elsevier, 2006)
Monitoring the efficacy of antiretroviral treatment in developing countries is difficult because these countries have few laboratory facilities to test viral load and drug resistance. Those that exist are faced with a ...
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
(Public Library of Science, 2006-05)
Objectives: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. Design: Randomized single-blind controlled trial. Setting: Tororo, Uganda, ...
Antenatal HIV testing in rural eastern Uganda in 2003: incomplete rollout of the prevention of mother-to-child transmission of HIV programme?
(BioMed Central, 2006-05-03)
Background: Uganda began to implement the prevention of mother-to-child transmission (PMTCT) of HIV programme in 2000, and by the end of 2003 it had expanded to cover 38 of the 56 districts including Mbale District. However, ...
Bacterial aetiology and outcome of severe pneumonia among children aged 2-59 months admitted to the Acute Care Unit, Mulago Hospital
(2006-05)
Introduction: Acute lower respiratory tract infections (ALRI) are a major cause of morbidity and mortality in the "under fives" worldwide, accounting for 10-30% of childhood deaths. Pneumonia contributes up to 50% of all ...