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Relationship between plasma levels of stavudine and self reported adherence rates to triomune in HIV/AIDS patients at the Joint Clinical Research Centre, Mengo Uganda.
(2009)
INTRODUCTION:
Adherence to antiretroviral therapy is mainly assessed by patient self reporting method in Uganda. The relationship between self reported adherence rates and plasma drug levels is not known. This study sought ...
Combined antiretroviral treatment modification among HIV infected patients in New Nyanza Provincial General Hospital, Western Kenya
(2012-06)
Background
Limited combined antiretroviral therapy (cART) regimens in resource constrained settings call for the need to optimize the available options in order to improve the durability of potent and well-tolerated first ...
Tenofovir related renal toxicity monitoring in antiretroviral therapy (ART) accredited sites: A situational analysis for Uganda
(Makerere University, 2014-09)
Background: In Uganda, Tenofovir-based regimen is recommended as first line particularly for HIV/AIDS adult and adolescent patient and for option B+ in prevention of mother-to-child transmission (PMTCT). As a result of ...
Simulation of clonal expansion and latent HIV reservoir size prediction using machine learning in virally suppressed individuals in Uganda
(Makerere University, 2022-07)
Background: HIV can survive as pro-viruses that do not undergo transcription mostly within resting memory CD4+ T cells despite prolonged antiretroviral therapy (ART). This Latent Viral Reservoir (LVR) has an extremely long ...
Whole exome sequencing uncovers genetic predisposition to pediatric HIV disease progression and hyperhemolysis syndrome
(Makerere University, 2022-07)
Background: Populations of African ancestry hold a disproportionate burden of infectious and non-infectious diseases. Genetic variants, with population allele frequencies ranging from rare to common variants, are believed ...
Low-abundance drug resistant variant patterns among HIV-1 patients with virological failure in Uganda
(Makerere University, 2022-03)
Background: The emergence and spread of antiretroviral drug resistant HIV-1 variants is one
of the major factors responsible for therapeutic failure in persons living with HIV (PLWH) as
it jeopardizes the efforts to ...
Effect of hydrocortisone hormone on in-vitro reactivation of HIV-1 reservoirs
(Makerere University, 2022-07)
The persistence of the HIV-1 reservoir in infected individuals represents a major hurdle to the development of a cure and complete eradication of HIV-1 infection. Stress hormones have also been shown to modulate immune ...
Metabolic syndrome among HIV positive patients on antiretroviral therapy attending the art clinic at Fortportal Regional Referral Hospital
(2022-10-18)
ABSTRACT
Introduction
The continuing evolution of potent antiretroviral therapy (ART) has resulted in dramatic reductions in HIV-associated morbidity and mortality. However, the availability of newer ART regimes has ...
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)
Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ...
HLA Class I and Pediatric HIV disease progression in Botswana and Uganda
(Makerere University, 2023)
Sub-Saharan Africa remains the global epicenter of the HIV epidemic; more than 70% (25 million) of all people living with HIV/AIDS are in Africa. To end the global epidemic, finding an effective HIV vaccine remains a top ...