Browsing by Author "Lamorde, Mohammed"
-
Antiretroviral therapy in developing countries: pharmacologic considerations
Lamorde, Mohammed; Byakika-Kibwika, Pauline; Merry, Concepta (Lippincott Williams & Wilkins, 2008)Purpose of review This article reviews recent studies in the field of clinical pharmacology of antiretroviral drugs and highlights the relevance of the findings to clinical practice in developing countries. Recent findings ... -
Artemether-Lumefantrine combination therapy for treatment of uncomplicated malaria: The potential for complex interactions with antiretroviral drugs in HIV-infected individuals
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Khoo, Saye; Merry, Concepta; Van geertruyden, Jean-Pierre (Malaria Research and Treatment, 2011-02-14)Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for ... -
Cost Effectiveness of a Pharmacy-Only Refill Program in a Large Urban HIV/AIDS Clinic in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Stergachis, Andy; Kiragga, Agnes; Shaefer, Petra; Lamorde, Mohammed; Kambugu, Andrew; Muwanga, Alice; Garrison, Louis P. (Public Library of Science, 2011-03-28)Background: HIV/AIDS clinics in Uganda and other low-income countries face increasing numbers of patients and workforce shortages. We performed a cost-effectiveness analysis comparing a Pharmacy-only Refill Program (PRP), ... -
Effect of food on the steady-state pharmacokinetics of tenofovir and emtricitabine plus efavirenz in Ugandan adults
Lamorde, Mohammed; Byakika-Kibwika, Pauline; Tamale, William S.; Kiweewa, Francis; Ryan, Mairin; Amara, Alieu; Tjia, John; Back, David; Khoo, Saye; Boffito, Marta; Kityo, Cissy; Merry, Concepta (Hindawi Publishing Corporation, 2012-02-20)We investigated the effect of food on the steady-state pharmacokinetics of a proprietary fixed-dose combination (FDC) tablet containing tenofovir disoproxil fumarate (TDF)/emtricitabine/efavirenz. Fifteen Ugandan HIV-1 ... -
Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Okaba-Kayom, Violet; Mayanja-Kizza, Harriet; Katabira, Elly; Hanpithakpong, Warunee; Pakker, Nadine; Dorlo, Thomas P. C.; Tarning, Joel; Lindegardh, Niklas; de Vries, Peter J.; Back, David; Khoo, Saye; Merry, Concepta (Journal of Antimicrobial Chemotherapy, 2012-02-08)Background: Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisininbased combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, ... -
Medical male circumcision for HIV/AIDS prevention in Uganda: the cost of disposable versus re-usable circumcision kits
Kuznik, Andreas; Lamorde, Mohammed; Sekavuga, Denis Bbaale; Picho, Brenda; Coutinho, Alex (Tropical Doctor, 2012-01-01)We evaluated the cost implications of medical male circumcisions for HIV prevention when performed using re-usable equipment that is sterilized after each use versus using single-use disposal kits. In Uganda, a re-usable ... -
Pharmacokinetic interactions between antiretroviral drugs and herbal medicines
Lamorde, Mohammed; Byakika-Kibwika, Pauline; Merry, Concepta (British Journal of Hospital Medicine, 2012-03-13) -
Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayito, Jonathan; Nabukeera, Lillian; Mayanja-Kizza, Harriet; Katabira, Elly; Hanpithakpong, Warunee; Obua, Celestino; Pakker, Nadine; Lindegardh, Niklas; Tarning, Joel; de Vries, Peter J.; Merry, Concepta (BioMed Central, 2012-04-27)Background: Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess ... -
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
Babigumira, Joseph B; Castelnuovo, Barbara; Lamorde, Mohammed; Kambugu, Andrew; Stergachis, Andy; Easterbrook, Philippa; Garisson, Louis P. (BMC Health Services Research, 2009-01-09)Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ... -
Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis
Manabe, Yukari C.; Hermans, Sabine M.; Lamorde, Mohammed; Castelnuovo, Barbara; Mullins, C. Daniel; Kuznik, Andreas (Public Library of Science, 2012-06)Background: In Uganda, isoniazid plus ethambutol is used for 6 months (6HE) during the continuation treatment phase of new tuberculosis (TB) cases. However, the World Health Organization (WHO) recommends using isoniazid ... -
Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayito, Jonathan; Nabukeera, Lillian; Namakula, Rhoda; Mayanja-Kizza, Harriet; Katabira, Elly; Ntale, Muhammad; Pakker, Nadine; Ryan, Mairin; Hanpithakpong, Warunee; Tarning, Joel; Lindegardh, Niklas; Khoo, Saye; Back, David; Merry, Concepta (Oxford University Press, 2012)Objectives: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug–drug interactions between artemether/lumefantrine and efavirenz ... -
Steady-state pharmacokinetic comparison of generic and branded formulations of stavudine, lamivudine and nevirapine in HIV-infected Ugandan adults
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Kalemeera, Francis; Mauro, Sciandra; Di Perr, Giovanni; Ryan, Mairin; Mayanja-Kizza, Harriet; Khoo, Saye; Back, David; Boffito, Marta; Merry, Concepta (Oxford University Press, 2008-07-19)Background: We aimed to compare the steady-state pharmacokinetic parameters and tolerability of Triomune 40w (stavudine 40 mg, lamivudine 150 mg and nevirapine 200 mg) and branded formulations of these drugs in HIV-infected ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; Van Geertruyden, Jean-Pierre (Dove Medical Press, 2009)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; van Geertruyden, Jean-Pierre (Dove Medical Press, 2009-12-16)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
Byakika-Kibwika, Pauline; Lamorde, Mohammed; Mayanja-Kizza, Harriet; Merry, Concepta; Colebunders, Bob; Van Geertruyden, Jean-Pierre (Dove Medical Press, 2009)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
“You would not be in a hurry to go back home”: Patients’ willingness to participate in HIV/AIDS clinical trials at a clinical and research facility in Kampala, Uganda
Sebatta, Deborah Ekusai; Siu, Godfrey; Nabeta, Henry W.; Anguzu, Godwin; Walimbwa, Stephen; Lamorde, Mohammed; Bukenya, Badru; Kambugu, Andrew (BMC, 2020)Background: Few studies have examined factors associated with willingness of people living with HIV (PLHIV) to participate in HIV treatment clinical trials in Sub-Saharan Africa. We assessed the factors associated with ...