Browsing by Subject "Drug resistance"
Now showing items 1-17 of 17
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Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda
(Public Library of Science, 2005-07)Background Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of ... -
Associations between aminoquinoline resistance genotypes and clinical presentations of Pplasmodium falciparum Infection in Uganda
(American Society for Microbiology., 2020)Mutations that mediate resistance of Plasmodium falciparum to aminoquinoline antimalarials are selected by prior drug use and may alter parasite fitness, but associations with clinical presentations are uncertain. We ... -
Detection of mutant P2 adenosine transporter (TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele-specific polymerase chain reaction
(Wiley-Blackwell, 2007)objective To assess the application of allele-specific PCR (AS-PCR) as a fast, cheap and reliable method for detecting mutant TbAT1 associated with melarsoprol relapse in Trypanosoma brucei gambiense isolates from northwest ... -
Drug-resistant bacterial contamination and efficacy of selected herbal medicines sold in Kampala city, Uganda (MakIR) (Unpublished PhD Thesis) Makerere University Kampala Uganda
(Makerere University., 2023-08-19)Background: Antimicrobial resistance (AMR), is when pathogens such as bacteria evade activities of drugs to which they were once susceptible, causing treatment failure. The AMR is escalating and is among the leading causes ... -
Genetic diversity of mycobacterium tuberculosis, drug resistance and atypical mycobacteria in Rwanda
(Regional Universities Forum for Capacity Building in Agriculture, 2016-10)The genus Mycobacterium has two main groups, Mycobacterium tuberculosis complex (MTBC) and atypical mycobacteria. The MTBC species, the causative agents of tuberculosis (TB), has been further typed into different genotypes. ... -
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
(Makerere University, 2010)Background Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ... -
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisinin combination therapy: complexity of infection during short-term culture and characterization of in vitro sensitivity in Kampala Uganda
(Makerere University, 2010)Background: Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant ... -
Genetic polymorphisms in plasmodium falciparum associated with resistance to artemisnin combination therapy: complexity of infection during short-term culture and characterization of in-vitro sensitivity in Kampala Uganda
(2010)Background Artemisinin-based combination therapy (ACT) is currently advocated in Africa as a means of improving treatment efficacy and slowing the development of drug resistance. However, the selection of resistant parasites, ... -
Incidence and factors associated with first line antiretroviral treatment failure in children attending the Joint Clinical Research Centre Kampala, Uganda
(Makerere University, 2012)Background: The human immunodeficiency virus (HIV) disease develops very rapidly among infants and children mainly due to the immature immune system. Without treatment, half of the children die before their second birthday. ... -
Initial drug resistance patterns to the essential anti-tuberculous drugs in previously untreated newly diagnosed pulmonary tuberculous patients attending Mulago hospital.
(2005)World Health organization (WHO) recommends a continuous assessment of tuberculosis (TB) drug resistant patterns as a means of assessing drug regimens and National Tuberculosis Programme (NTP) performance. In addition, an ... -
The molecular biology of sulfadoxine-pyrimethamine drug resistance of plasmodium falciparum strains in Uganda
(Makerere University, 2007-08)In November of 2000, Uganda changed its anti-malarial policy to replace chloroquine (CQ) with a combination of CQ and sulphadoxine–pyrimethamine (SP) as the first line agents. The idea of the combination was to delay the ... -
Multiple HIV-1 subtype infection and transmitted drug resistance; prevalence in HIV-1 infected Ugandans and association to disease stage and progression
(Makerere University, 2011-08)Infection of an individual with two or more viral strains (dual/mixed infection) occurs in HIV-1 infection. The identification of the immunological and virological determinants of dual infection would provide data that ... -
Predictors of treatment failure among patients with smear positive pulmonary tuberculosis in the tuberculosis clinic in Mulago Hospital: a case control study
(2008)Background: Treatment failure is a threat to the control of tuberculosis (TB) because of its association with Multi Drug Resistant tuberculosis (MDR TB) and also because affected patients continue to spread TB. Patients ... -
PREVALENCE OF VIROLOGICAL SUPPRESSION AND PATTERNS OF ACQUIRED HIV DRUG RESISTANCE AMONG INDIVIDUALS ON FIRST-LINE ANTIRETROVIRAL THERAPY IN FISHERFOLK COMMUNITIES IN UGANDA
(2018-10-03)Background: The UNAIDS targets sustained viral suppression among at least 90% of HIV individuals on antiretroviral therapy (ART), yet viral load (VL) monitoring is rarely done in resource-limited settings due to high costs. ... -
Real-time imaging of the intracellular glutathione redox potential in the malaria parasite plasmodium falciparum
(Public Library of Science, 2013-12)In the malaria parasite Plasmodium falciparum, the cellular redox potential influences signaling events, antioxidant defense, and mechanisms of drug action and resistance. Until now, the real-time determination of the redox ... -
The TB pandemic: an old problem seeking new solutions
(Blackwell, 2007)Meya DB, McAdam KPWJ (Infectious Disease Institute, Kampala, Uganda). The TB pandemic: an old problem seeking new solutions (Review). J Intern Med 2007; 261: 309–329. Tuberculosis (TB) continues to kill more than 2 million ... -
The TB pandemic: an old problem seeking new solutions
(Blackwell, 2007)Tuberculosis (TB) continues to kill more than 2 million people globally each year. Annual TB case notification rates have risen up to fourfold since the mid-1980s, with the highest rate of 1000/100 000 around Cape Town, ...